Polynucleotides
Regenerate. Heal. Illuminate
Looking for deep skin regeneration without adding volume?
When your skin needs more than hydration—when you’re dealing with inflammation, damage, or that stubborn dullness that nothing seems to shift—polynucleotides work on a cellular level where real transformation begins.
These next-generation biostimulators improve healing, boost collagen, and restore skin health from within. Perfect for delicate areas like under-eyes, neck, or anywhere your skin feels tired, crepey, or compromised.
This is skin rehabilitation—gentle, powerful, and profoundly restorative.
Ready to transform your skin at the deepest level?
Book your consultation
No. of Treatments
Individual
Procedure Time
30 Minutes
Results
12-18 weeks
Longevity
3-6 Months
ANAESTHETIC
Used
Risk & Complications
Swelling, bruising and infection (rare)
Recovery Time
48 hours – 1 week
Back to Work
Immediate
No. of Treatments
Individual
Procedure Time
30 Minutes
Results
12-18 weeks
Risk & Complications
Swelling, bruising and infection (rare)
Recovery Time
48 hours – 1 week
Back to Work
Immediate
What are Polynucleotides?
Polynucleotides represent the pinnacle of regenerative aesthetic medicine. Derived from salmon DNA, these advanced biostimulators contain long-chain molecules that act as powerful cellular messengers, triggering profound skin repair and regeneration.
When injected, polynucleotides activate fibroblast cells—the factories that produce collagen and elastin in your skin. This creates a natural healing response that goes far beyond surface improvements, working at the cellular level to rebuild damaged tissue and restore optimal skin function.
The treatment delivers over 20 billion high-purity exosomes along with powerful growth factors, creating comprehensive skin regeneration that addresses everything from inflammation to structural damage.
How do Polynucleotides work?
Cellular activation: Polynucleotides wake up dormant cells and stimulate fibroblast activity Tissue regeneration: They trigger natural healing responses that rebuild damaged skin from within
Hydration and antioxidant properties: These molecules attract water while protecting against free radical damage Collagen renewal: Stimulate your body’s own collagen and elastin production for lasting structural improvement
This isn’t just skin improvement—it’s genuine skin rehabilitation that addresses the root causes of aging and damage.
What skin conditions can be treated?
Age-related concerns:
- Fine lines and wrinkles through genuine collagen renewal
- Loss of skin elasticity and firmness
- Dehydrated, dull complexion that lacks vitality
- Crepey skin texture, especially around delicate areas
Damage and inflammation:
- Post-inflammatory pigmentation and uneven tone
- Acne scarring and textural irregularities
- Rosacea, redness, and skin sensitivity
- Sun damage and photoaging effects
Advanced applications:
- Under-eye area rejuvenation without adding volume
- Neck and décolletage restoration
- Scalp treatments for hair health and regrowth
- Any area requiring cellular-level repair
What makes polynucleotides different?
Genuine regeneration: Unlike fillers that add volume or skincare that works on the surface, polynucleotides actually repair and regenerate skin cells No volume addition: Perfect for delicate areas where traditional fillers aren’t suitable Comprehensive healing: Addresses multiple skin concerns simultaneously through cellular repair Scientific advancement: Represents the latest in regenerative medicine applied to aesthetics Long-lasting transformation: Results develop over months as your skin genuinely rebuilds itself
This is the future of skin treatment—working with your body’s natural healing mechanisms to create profound, lasting change.
What areas can be treated?
Facial rejuvenation:
- Under-eye area for brightness without puffiness
- Neck and jawline for tightening and smoothing
- Full face for comprehensive skin quality improvement
- Décolletage for chest rejuvenation
Specialized treatments:
- Scalp for hair follicle health and regrowth
- Areas with previous sun damage or scarring
- Sensitive skin areas where other treatments aren’t suitable
- Any region requiring cellular-level healing
The versatility of polynucleotides makes them suitable for treating areas and concerns that other treatments simply cannot address effectively.
How to prepare
Please ensure you arrive to your appointment make up free.
Ask as many questions as you feel necessary. Im here to help you.
If its your first time, try and stay relaxed and remember – you are here for a reason. It can be an exciting time, working with you to improve something that may be affecting you. Or for the simple reason that you just want a refresh and improve what you’ve already got, whilst still looking natural.
The downtime of treatments can be minimal for most undertaking them, with bruising being the most common risk. Although bruises are only temporary, here are some suggestions to help your experience be the best it can be and how to prepare for your treatment.
To minimize the chance of bruising following injections:
- Avoid alcohol 48hrs prior to your appointment
- Consider taking arnica 5-7 days before your appointment
- Stay well hydrated for 24 hours prior to your appointment
The following medication, this may increase your risk of bruising:
- Aspirin
- Ibuprofen/naproxen
- Vitamin E
- Fish oil
- St Johns Wort
- Ginseng
Please Note: if you have been prescribed medication for a medical condition, please ensure you speak to an appropriate medical professional before stopping medication.
What to expect after treatment
You’ll notice an immediate glow and hydration boost right after treatment — that’s the hyaluronic acid getting to work. But the real magic happens over the following weeks as your skin continues to improve.
Over 2-4 weeks, you’ll see skin texture become smoother, fine lines soften, and that radiant, plump look intensify. Your skin will feel more supple and resilient, and makeup will sit beautifully because your skin is genuinely healthier from within.
Most people need 2-3 treatment sessions spaced 2-4 weeks apart for optimal results, followed by maintenance treatments every 6-9 months. During your consultation, we’ll create a treatment plan tailored to your skin’s specific needs.
Results typically last 6-9 months, but because skin boosters actually improve your skin quality rather than just filling lines, the benefits build with each treatment. You’re investing in long-term skin health, not just a temporary fix.
I’ll see you for a review appointment to assess how your skin is responding and plan your next session if needed.
Aftercare
Please ensure that the following aftercare instructions are fully adhered to, to avoid adverse reactions.
Use a gentle cleanse and water to clean the face for the following 72hours. Gently dry the treated area. Always make sure the hands are clean before touching the treated area.
Ensure you keep well hydrated following treatment and use creams which hydrate the skin and aid skin healing. Serum antioxidants can help soothe skin and contain properties that promote skin healing.
To ensure a proper healing environment following treatment, it is advisable to avoid the following:
For up to 24hrs:
- Alcohol consumption
- Applying make-up
- Touching or rubbing the treated area
- Strenuous exercise or activity. Sweating and gym environments may increase harmful bacteria and may cause adverse reactions.
For at least 3 days post treatment:
Do not use any Alpha Hydroxy Acids, Beta Hydroxy Acids, Retinol (vitamin A), Vitamin C (in a low pH formula) or anything perceived as ‘active’ skincare.
For up to 2 weeks:
- Extreme facials and facial massage
- Extreme sun exposure
- UV light
- Temperatures below 0 degrees
- Saunas and steam rooms
- Wearing well fitted garments on the treated area – such as hats
If you have any concerns following your treatment or would like to arrange a follow up appointment, please contact the clinic at your earliest convenience
Why Choose The Little Clinic?
My patient’s need’s are my priority, my aim is to not only help achieve your goals with your treatment but improve the quality of your life in a more meaningful way.
I take pride in the service I provide to my patients and provide a service I would like to receive as a patient myself.
I take time and listen to my patients so I can work with them and build a trusting relationship. My aim is to help you look and feel better about yourself and your appearance so you can go out into the world with more confidence, self love and feel you are glowing within your own skin. Looking and feeling the best version of yourself, in a natural harmonious way.